A convenient, accessible, and high yield method for preparing of 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (1) by\ntreatment of acetoacetic acid ethyl ester with thiourea in sodiummethylate was developed.Thealkylation of the latter with 3-chloropentane-\n2,4-dione and further regioselective cyclization of intermediate compound (2) in high yield afforded 2-acetyl-3,7-dimethyl-\n5H-thiazolo[3,2-a]pyrimidin-5-one (3). The halogenation and some transformations of synthesized thiazolo[3,2-a]pyrimidine (3)\ndue to its ketone group were carried out to obtain the corresponding carboxamide, carbothioamide, sulfonohydrazide, and oxime\nand its alkylated derivatives (5). At preliminary biological studies the synthesized compounds have shown growth stimulant\nproperties. The activity of four of them was higher than 70%, compared with heteroauxin.
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